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Survival after diagnosis of colorectal cancer is higher for those with higher serum 25(OH)D levels.
Based on post-diagnosis predicted 25(OH)D levels on mortality among 1017 participants in the Nurses' Health Study and Health Professionals Follow-Up Study who were diagnosed with colorectal cancer from 1986 to 2004 with levels in the lowest quintile, participants with predicted 25(OH)D levels in the highest quintile (31.0 ng/mL (range 29.7 ng/mL –34.9 ng/mL) had an adjusted hazard raio of 0.50 (95% confidence interval (CI), 0.26-0.95) for cancer-specific mortality and 0.62 (95% CI, 0.42-0.93) for overall mortality compared to those in the lowest quintile (23.3 ng/mL (range 19.1 ng/mL – 24.8 ng/mL)1. This paper extended the results reported earlier2.
A similar study in Japan with about one-third as many cases as the Ng. et al1 study found a beneficial effect for rectal cancer but not colon cancer3.
A study in the United States found that vitamin D deficiency explained 40% of the disparity in colorectal cancer survival between black and white Americans4.
Page last edited: 22 August 2011
- Ng, K. Wolpin, B. M. Meyerhardt, J. A. Wu, K. Chan, A. T. Hollis, B. W. Giovannucci, E. L. Stampfer, M. J. Willett, W. C. Fuchs, C. S. Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. Br J Cancer. 2009 Sep 15; 101 (6): 916-23.
- Ng, K. Meyerhardt, J. A. Wu, K. Feskanich, D. Hollis, B. W. Giovannucci, E. L. Fuchs, C. S. Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer. J Clin Oncol. 2008 Jun 20; 26 (18): 2984-91.
- Otani, T. Iwasaki, M. Sasazuki, S. Inoue, M. Tsugane, S. Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. Br J Cancer. 2007 Aug 6; 97 (3): 446-51.
- Fiscella, K. Winters, P. Tancredi, D. Franks, P. Racial Disparity in Blood Pressure: is Vitamin D a Factor?. Journal of general internal medicine. 2011 Apr 21;