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I had a local lab test 25 OH(D) in early May of 2016. The results were reported as 29L which I assumed meant 29 ng/mL as the references on the sheet were all of the form ng/mL. I get very little sun as my normal awake hours are largely at night. I began taking 5000 units D and 100 mcg K2 daily with breakfast. In October of 2016 I had a second lab test. These results were listed as 51. Again their reference levels were in ng/mL so I assumed 51 ng/mL Early this month a third test reported 31 pg/mL. Their reference range was listed as 18-72 pg/ml, without any breakdown into categories as on previous tests. A picogram being .001 nanogram, my levels seem to have virtually disappeared. Does this change in nomenclature have any reasonable meaning? Guessing that they screwed up the reporting units but not the test, there was still a large drop in my levels while taking the same dose. Aside from the possibility that the manufacturer stopped putting actual active ingredients into their capsules, is this a recognized symptom of anything?

Asked by  ahahx49990300 on March 27, 2017

  •  ahahx49990300 on

    See title

    Answered by  ahahx49990300 on
  •  IAW on

    In my opinion (like yours) the 31 is probably not pg/ml but ng/ml. Your very first reading in May 2016 seems a little suspicious as to how “high” it was considering the lifestyle you describe. Since it was a May reading though, maybe there was a “little sunshine” in the reading and the rest was from food or fortified food.
    The October 2016 reading seems fair considering you were taking 5000iu. If it did have some “sunshine” in the reading than that would mean that 5000iu is not really enough for the winter. Do you weigh a lot more than 150lbs?
    This months 31 could be like I said above, not enough for winter or perhaps you now weigh more.
    It could be the lab cannot perform the test correctly or uses an older less reliable method. It could be the actual vitamin D you take is not very reliable, some are not. (The only one the VDC guarantees and/or promotes is Biotech and that it contains the amount it says it does.)
    Your last question is could a disease or sickness be causing the drop? Before taking any Vitamin D did you have any “health issues” or “gain” any along the way up to this point? If not then I do not think this is the issue. If you have, then you should let me know.

    Answered by  IAW on
    •  ahahx49990300 on

      Nothing about my health has changed recently as far as any symptoms I recognize or recent lab test reveal.

      I contacted the producer of the Vit D supplements about the possibility of the capsules containing a lesser than advertised amount. Their wrote back that their Product Specialist assure them that
      “the Vitamin D 5000 IU (SW1371) that was mentioned, has been quality tested for purity and potency. It does meet the label claims on the product itself and they do not see any changes in the product.”
      I guess that is the best I can hope to get without some large amount of money for independent testing.

      Originally I was also taking a daily multi-vitamin tablet. Having read that vit A retinyl acetate or perhaps retinyl palmitate, interferers with the absorption of vit D, and seeing that my tablets contained that form, I took the D and K with breakfast and the multi vitamin in the evening. Soon I purchase a better multi-vitamin. It claims that it’s A comes as beta carotene.

      For a long while I continued to separate the two doses. However, while it is fairly easy for me to remember the morning pills, I frequently forget in the evening. A couple months ago I started taking all in the morning since, as far as I know, there is no proscription against consuming them together. However, if taking any form of A with the D is a problem, that might explain the test results.

      A third possible consideration is sunlight. I accepted the apparently widely held belief that where I live there would only be adequate UVB during less than half the year and only for one to two hours on either side of noon. I am essentially never in the sun at that time. However, I do get some sun, from a half hour to sometimes possibly two hours (cumulative, not continuous) later in the afternoon, two or three days most weeks. According to the “Latitude Hypothesis” this should not be very helpful but I recently ran across this article which questions it

      Vitamin D — Problems With the Latitude Hypothesis

      Maybe the large difference in my test results between now and last October are due to summer sun vs winter rain. That idea perhaps suggest that I should take maybe twice as much in the winter — if higher levels are indeed beneficial.

      Answered by  ahahx49990300 on
  •  IAW on

    You said “Having read that vit A retinyl acetate or perhaps retinyl palmitate, interferers with the absorption of vit D”. Vitamin A is a co-factor for Vitamin D and on this website I have never read anything like you stated above, so I think that was perhaps bad information. Having said that Dr.Cannell says to be very careful how much “preformed” Vitamin A one ingests and not to ingest more than the RDA. Beta Carotene is the “safer bet” but foods are fortified with “preformed”.
    The next thing was “That idea perhaps suggest that I should take maybe twice as much in the winter — if higher levels are indeed beneficial.” Just to let you know, 10,000iu is the “official” safe upper limit. You could take 10,000iu over the winter but you probably only really need 7000-8000iu to get you to the 50ng/ml. I would try and at least get to 40ng/ml, for the winter which probably means taking 6-7000iu. Too many studies show that at levels below 40ng/ml and your risk for cancer and autoimmune disease rises “dramatically”.
    I really think the level difference is because you are getting some sunshine in the summer and in the winter you just need some more.
    As for the article I did read it and he came to some wrong conclusions, has some misinformation in it and he is not an “expert” on Vitamin D. When I originally found this website (VDC) and started reading, I actually went back and read everything Dr. Cannell had posted over about 3-4 years. That’s how fascinated I became on the subject and the “light bulb” moment I had. So although I am not a scientist or a doctor, I do believe that Dr. Cannell, Hollick, Veith and Heaney, all know what they are talking about! (I also think I am missing a name.)
    I am not a subscriber to this but maybe you want to look at it. This page tells you how much it costs https://www.consumerlab.com/newsubscriber.asp but you can go to the home page for more info.
    If you have more questions, just ask!

    Answered by  IAW on

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