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Hi , I am suffering from very severe crohn's disease and saw some good results when supplementing 20000 I.U daily, very much magnesium (i.v.), vitamin K2, zink and boron. I've been doing this for 6 weeks. However I still have to take prednisone 10 mg and other immunesuppressive medications because otherwise I would get very high fever (Before starting supplementation I had to take 20 mg prednisone not to get high fever and then I noticed that magnesium in combination with D and K2 dramatically reduced this overshooting reaktion). I would like to know if there is any correlation between prednisone intake an vitamin D-25 metabolism? What I've also have found is that there are controversal facts about vitamin A interaction with vitamin D. Some studies have found synnergetically positive action of both on overactive immunity. Other say that vitamin A is contraproductive and that Vitamin A blocks the action of vitamin D on vitamin D receptor. What is your opinion in this question? Eugen

Asked by  Eugen on February 8, 2015

  •  Eugen on

    See title

    Answered by  Eugen on
  •  IAW on

    I am so very glad that the Vitamin D and its cofactors are making you better! I think you are making great progress in that you have been able to cut back on your prednisone intake and it has only been 6 weeks! With more time and continued Vitamin D you will probably eventually not need any prednisone.
    Prednisone is given to reduce the inflammation that occurs with Crohn’s. Since Vitamin D has its own “anti- inflammatory” properties, this is why you need less prednisone. You may like to read http://www.vitamindcouncil.org/health-conditions/inflammatory-bowel-disease/. An excerpt from this is “In IBD, vitamin D works in the immune system by reducing levels of inflammatory proteins that get overproduced. One of the proteins that vitamin D can lower is called tumor-necrosis factor, or TNF. One of the medications to manage IBD involves blocking TNF production. Therefore, researchers think that vitamin D may be a natural way to block TNF and help reduce inflammation in the digestive tract4,6.”
    As for Vitamin A you may like to read http://www.vitamindcouncil.org/about-vitamin-d/vitamin-d-and-other-vitamins-and-minerals/ the subsection about Vitamin A. Vitamin D and Vitamin A work together and you need both. It is felt that most of the issue is that too much “preformed Vitamin A”, like retinol, is really the issue. So it is best to take beta carotene and not very much, if any, “preformed A”.
    Please update us later on your condition! We like to hear “Vitamin D success stories”!

    Answered by  IAW on
  •  Eugen on

    Here is a small update on my condition. After doing some research I decided to add the retinol and not the beta-carotin to my therapy.
    Why? Well, I found that there may be some difficulties due to conversion of beta-carotin to retinol, if your body doesn’t have enough resources to convert it. http://www.nleducation.co.uk/resources/reviews/vitamin-a-the-key-to-a-tolerant-immune-system/
    The result is quite incredible. After only one day of taking 30000 i.U of retinol I felt another great improvement, My bowel movements reduced further dramatically and I visit the bathroom only twice a day now (before starting the whole therapy 10-15 times were day were normal for me). Today is the third day of taking retinol and I think that I am starting to gain some weight. Still no fevers and I am reducing the prednisone very slowly not to cause relapse. Taking 8.5 mg of prednisone now.
    Of course, I understand that my intake of vitamin D and its cofactors also play a dramatic role in my improvement but in my case (and I believe that every disease is a special medical case due to its unique chemical parameters) I believe that Vitamin A is a very important cofactor. My experience may show that in the process of mucosal healing Vitamin A and Vitamin D are cofactors and not competitors as suggested in some medical papers.
    However, I do not negate the possibility that in other conditions Vitamin A may play a negative role due to its interaction with vitamin D. So people who read my positive report should be careful and listen to their symptoms when they introduce retinol or beta-carotin to their therapy.

    Answered by  Eugen on
  •  IAW on

    I am soooo happy you are feeling better and may you only have further improvement.
    You are very correct in that the preformed A, in your case, is probably the right choice and especially at this time.
    If the disease/problem you are battling at the time is intestinal or absorption centered, then preformed may be the way to go. (I will add the knowledge for future reference in helping people. I will also read the above link.
    Please update us again later!!

    Answered by  IAW on

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