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Effect of supplementation on vitamin D status: Thin and obese women

Posted on: January 12, 2013   by  John Cannell, MD


Many studies have shown an inverse relationship between 25(OH)D and obesity. Some possible explanations include the popular fat sink (increased storage in the adipose tissue), sedentary lifestyle of the obese, low sunlight exposure among the obese, genetic changes in obesity or other unknown factors. The concept of a fat sink is popular but no randomized controlled trial ever explored the issue. Animal studies show that the vitamin D is stored in muscle, liver and skin, as well as fat.

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1 Response to Effect of supplementation on vitamin D status: Thin and obese women

  1. Rita and Misty

    I’m wondering if the rate of increase would slow down once a sufficient 25(0H)D level is reached in one’s body….

    Using myself as an example: my 25(OH)D levels as of 1.1.13 is 104 ng/ml. This is after supplementing with 32,000 iu of D3 daily since 10.1.12…..During the summer, my level was around 75 ng/ml with 16,000 iu D3 daily, and approx 2.5 hours of high sun per week (Connecticut’s version of sun)

    I’ve since cut back to 24,000 i.u. D3 daily…

    Since my body is completely sufficient now regarding Vitamin D, I am thinking that even with a high does of 24,000 i.u. D3 daily, the rate of increase will slow down….

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