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Dr. Cannell’s letter to Professor JoAnne Manson

Posted on: March 26, 2018   by  John Cannell, MD


JoAnn E. Manson, MD, DrPH
Harvard Medical School
900 Commonwealth Avenue, 3rd fl
Professor of Medicine and the
Michael and Lee Bell Professor of Women’s Health
Chief, Division of Preventive Medicine
Brigham and Women’s Hospital
Boston, Massachusetts 02215
Ph: 617-278-0871; Fax: 617-731-3843
Email:  jmanson@rics.bwh.harvard.edu

RE: Your March 6, 2018 JAMA publication.

Dear JoAnn:

I enjoyed your Viewpoint – in the 3/6/2018 JAMA – making the case supplements are usually worthless and occasionally dangerous, including vitamin D.  However, you did not answer my previous questions.  To the best of my knowledge, here are the correct answers:

  1. As a world respected Harvard University vitamin D expert, remind me how many cases of toxicity and/or deaths did Poison Control report from the 25,397 Americans who overdosed on vitamin D over the last 15 years? 
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10 Responses to Dr. Cannell’s letter to Professor JoAnne Manson

  1. richardfwaters

    Talking to her is like yelling out the window. Her entire department disputed everything she said about D and yet she is still there. I had an endocrinologist also on the staff at Harvard Medical school. For 3 years he treated my osteoporosis, D 22, with Fosamax with no improvement and finally admitted he hadn’t the foggiest idea, idiopathic, why I had osteoporosis. At that point I realized I needed more D and treated myself with dramatic improvement. Harvard has no problem with idiots and quacks in my opinion.
    Harvard Medical School is a mixed bag and not a mark of competence in my opinion.

  2. ihodgson@slingshot.co.nz

    Obviously I agree with this statement by the Prof. Manson. In fact I wish that clinicians follow this:
    “Clinicians have an opportunity to promote appropriate use and to curb inappropriate use of micronutrient supplements, and these efforts are likely to improve public health.”

    Unfortunately many clinicians have not a clue on doing this. It would be great if primary physicians learned more about supplementation especially of Vitamin D. Sadly Prof. Manson’s paper reflects a common bias of “opinion before evidence” – arising from a poor understanding of the literature on supplemental use in Medicine, especially of vitamin D.

    I wonder if Dr. Cannell’s questions will ever be answered.

  3. meblaker26028900

    Is Dr Manson related to Charles Manson?
    She needs to study Dr Cicero Galli Coimbra’s massive research and successes with toxic megadoses of D3.

  4. tsandypaws

    I’ve been treated for my MS for the last 8 years after almost medication poisoning (copaxone) , with 20,000 IU of D with magnesium and k2. Numbers have not exceeded 83. Doing very well on this protocol.

  5. fredglass

    Never ever. JoAnn Manson M.D. won’t even read Dr. Cannell’s letter. But at least reader’s of this blog will be disabused of false hopes that esteemed physicians of Harvard Medical School necessarily know what they are talking about.
    Fred Glass

  6. JKenL77760

    This is just typical of mainstream medicine that knows nothing about supplements and actually fears that patients will be kept healthy which in our system of fee for service medicine will decrease profits for doctors and hospitals and pharmaceutical companies which is their true objection but they will never admit to it.

  7. David

    The basic question of danger in supplements was answered by Dr Andrew Saul and may be found at doctoryourself.com Saul examined the medical records and found there was less than half a death per year from supplements of all kinds. As a comparison taking a vitamin is about a thousand times safer than taking any form of acetaminophen which is a over the counter drug. What ever the JAMA complains about, they should spend a thousand times more press space on OTC drugs being dangerous!

  8. rcbaker200@comcast.net

    About 6 years ago Dr.Manson was on a Boston radio station talking about vitamin D (it was somewhat of a hot topic then). Paraphrasing what she said, “No research has been done on vitamin D, but I am doing the research now and once I finish it, we will know about vitamin D.” At this time there was already extensive research on vitamin D. The arrogance of any physician who would say this is incredible. And yet she gets away of it, probably because of the misplaced prestigue of the institution she is affiliated with.

  9. rcbaker200@comcast.net

    Sooner or later someone in authority is going to have to come right out and say the following.
    1. Evidence based medical studies indicate the benefit of vitamin D levels of 40 to 60 ng (100 to 150 nMol).
    2. The evidence indicates that the benefit with osteoporosis, cancers, autoimmune diseases including MS, and infections is substantial and real.
    3. Many studies that get publicity use small doses of vitamin d that don’t raise the level to 40 to 60 ng., in fact many subjects never go over 25 ng.
    4. If the benefits of vitamin D became known to the general public, the impact on medical expenditures and to the medical profession’s income would be substantial. The evidence suggests that hiding the benefit of vitamin D from the public by deliberately flawed studies is in many cases deliberate in order to not have a negative effect on the medical industry’s income. This can be compared to the flawed studies of DES in the 1940’s and 50’s that lead to the widespread prescribing on DES in pregnant women, and the result in that case was the death of thousands of women in their 20’s from a rare DES caused tumor.
    5. The facts that vitamin D is not really a vitamin; and it is the only substance called a vitamin that cannot be supplied in sufficient quantities routinely by diet, and that the amount of natural source of vitamin D in humans (sunlight) has been drastically reduced from the time that humans lived near the equator – all these factors contribute to the tragic confusion related to vitamin d among the general population.
    I have obtained 25-hydroxyvitamin D levels on 12,000 people in 14 years and I have seen the objective benefit from treating vitamin D insufficiency to the levels of 40 to 60 ng (100 to 150 nMol.)

  10. tick6

    Tsandypaws , very glad to hear you are doing ok , I had my level of d was 10.4ng/ml , 3 months on d 3000iu a day , now 54ng/ml could you let me know how king you started to feel less pain , I have M.E but understand osteomachia from deficiency can cause dreadful bone and muscle pain , ive hardly been able to move at times , very upsetting but hoping in months to come carrying in with supplements if vitamin d will help me.

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