Does vitamin D help treat Crohn’s disease?

Posted on: November 18, 2015   by  John Cannell, MD

img

Dear Dr. Cannell:

This story is from Norway, and is about my 18-year-old son. He was diagnosed with Crohn’s disease about 6 years ago. He was prescribed medicine and his condition improved, but he also experienced many side effects. He was depressed and stopped his medication regimen. However, he soon became ill again, and restarted his medication for a second time.

The cost of the medicine was 12,000 NOK/month ($1380 USD), paid by the government, but still a lot of tax money in a lifetime. 12,000 times 12 months times sixty years = 8.6 million NOK = 1 million dollars in big Pharma Industry revenue.

In the meantime, I become more aware of the benefits of vitamin D in general, but not the connection with Crohn’s. I had given my son 5000 IU/day for about half a year when he started school on the west coast of Norway, about 500 km away from home.

Without my knowledge he ended his Crohn’s medication again. This time he did not get sick again. For 5 years now he has taken his vitamin D and not any Crohn’s medicine. There was no other change in his life that I know of that would have had such an effect on his Crohn’s.

This is a lot of savings for society but even better, my son has his life back.

Thank you for all you do.

Tor Guston, Norway

Dear Tor:

That is great news. High dose vitamin D sometimes helps. However, in my experience, not all patients with Crohn’s disease are helped with vitamin D and some may not respond as well to the newer treatments. I knew a woman who was so convinced high-dose vitamin D was the answer she refused medications such as Adalimumab (Humira®), Certolizumab pegol (Cimzia®), Infliximab (Remicade®), Golimumab (Simponi®), Natalizumab (Tysabri®) and Vedolizumab (Entyvio®).  She ended up getting severe complications including a number of fistulas.

However, there is now a meta-analysis showing patients with inflammatory bowel diseases have lower vitamin D levels than controls.

Del Pinto R, Pietropaoli D, Chandar AK, Ferri C, Cominelli F.Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis. Inflamm Bowel Dis. 2015 Nov;21(11):2708-17.

There is also new evidence that low 25(OH)D levels in Crohn’s are associated with worse disease activity.

Raffner Basson A, Swart R, Jordaan E, Mazinu M, Watermeyer G. Vitamin D Deficiency Increases the Risk for Moderate to Severe Disease Activity in Crohn’s Disease Patients in South Africa, Measured by the Harvey Bradshaw Index. J Am Coll Nutr. 2015 Oct 2:1-12.

However, there is also a new study indicating vitamin D deficient patients with Crohn’s respond better to Remicade!

Reich KM, Fedorak RN, Madsen K, Kroeker KI. Role of Vitamin D in Infliximab-induced Remission in Adult Patients with Crohn’s Disease. Inflamm Bowel Dis. 2015 Sep 9. 

With that being said, a recent review reported vitamin D appears to have a treatment effect in inflammatory bowel diseases such as Crohn’s disease.

Hlavaty T, Krajcovicova A, Payer J. Vitamin D therapy in inflammatory bowel diseases: who, in what form, and how much? J Crohns Colitis. 2015 Feb;9(2):198-209.

What should you do if you have Crohn’s disease? My advice is to find a good gastroenterologist and do what he/she says. Despite the above study of showing Remicade works better in the vitamin D deficient, the other risks of vitamin D deficiency are too great to ignore. Therefore, I recommend supplementing with 10,000 IU daily on days that one is unable to receive safe, sensible sun exposure.

1 Response to Does vitamin D help treat Crohn’s disease?

  1. hlahore@gmail.com says

    The very latest publication on the topic
    Is vitamin D supplementation a viable treatment for Crohn’s disease – Nov 2015
    http://vitamindwiki.com/tiki-index.php?page_id=7098

Test Your Vitamin D Levels at Home!

Our in-home Vitamin D Test Kit is easy, affordable, and an accurate way to find out your Vitamin D status.

order NOW

We need your help!

We're spreading awareness on Vitamin D Deficiency
Donate NOW
Latest Articles
img
New study suggests higher vitamin D levels associated with reduced risk of mortality

A recent study found that vitamin D levels above 32 ng/ml are associated with reduced risk of mortality caused by coronary heart disease.

Weekly Newsletter