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Does liver disease confound vitamin D studies?

Posted on: January 14, 2014   by  Brant Cebulla


Liver disease may cause vitamin D deficiency. The liver is responsible for converting your vitamin D into circulating form 25(OH)D. There are a few different explanations why liver disease may cause vitamin D deficiency.

In cholestatic liver diseases, conditions where bile flow cannot flow from the liver to the duodenum, cholestasis reduces the intestinal availability of bile salts needed for the absorption of fat-soluble vitamins. It also affects the conversion of vitamin D to 25(OH)D. Furthermore, parenchymal liver disease may cause abnormalities of vitamin D metabolism, also causing vitamin D deficiency.

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2 Responses to Does liver disease confound vitamin D studies?

  1. [email protected]

    Perhaps because people were dying of liver disease before dying of other longer-term vitamin D deficiency related diseases.

  2. [email protected]

    There are several other forms of vitamin D for those with liver or gut problems

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