VDC test kit slider

Dear Dr Cannell: Proud to report PSA levels

Posted on: August 14, 2012   by  John Cannell, MD


Dear Dr. Cannell:

I have low-grade prostate cancer and take vitamin D. I started taking 15,000 IU of vitamin D3 a day in 2007. I have reduced the amount of vitamin D3 from 15,000 IU to 10,000 ILI because my 25(OH)D in September 2010 showed 132. In October2011 my 25 (OH)D was 130 so I reduced it to 4500 IU a day.

In February 2012, it showed greater than 94 so my doctor told me to take about 3250 IU of vitamin D3 daily. Below are my PSA levels.

PSA Levels 2007-2012

  • March 2007:  7.57
  • April 2008:  4.7
  • April 2009: 5.8
  • July 20l0: 5.8
  • 2011 none
  • March 2012:  2.4

Thank you for offering me the opportunity to help others, thanks for protecting my confidentiality and thanks for all you do.


Charles Smith

Dear Mr. Smith:

Congratulations, your PSA is now near normal. In Dr. Marshal’s recent study, 4,000 IU per day kept PSA levels stable during the year of the study but 60% of the men showed biopsy improvement.

Marshall DT, et al. Vitamin D3 Supplementation at 4000 International Units Per Day for One Year Results in a Decrease of Positive Cores at Repeat Biopsy in Subjects with Low-Risk Prostate Cancer under Active Surveillance. J Clin Endocrinol Metab. 2012 Jul;97(7):2315-24. Epub 2012 Apr 16.

Since you started at such a high dose of vitamin D, and changed doses, it is difficult to know if your high blood levels were responsible for lowering your PSA. Your lowest PSA was when your level should have been about 80 ng/ml.

Though anecdotal, I had a patient, an African American man, whose PSA was 20. 5,000 IU/day appeared to bring it down to four over the next year. He then stopped the vitamin D and his PSA shot up to 18 over the next 6 months.

It appears the right dose of vitamin D may lower PSA levels in some men and that dose is more than 4,000 IU/day. It may require high normal 25(OH)D levels, around 80 ng/ml. Higher than that is not necessarily any better.

2 Responses to Dear Dr Cannell: Proud to report PSA levels

  1. [email protected]

    I noticed the same with my father´s PSA too. I managed to get him below 2.0. He is dead now, but not due to the prostate cancer.
    It has been some years now, so I didn´t know then, that I should have given at least 5000 IU a day. That is my belife today, that most people need at least 5000 IU on a daily bases.
    But he got ~3000 IU a day and of course selenium and zink (and a multivitamin-mineral tablet).

    My father had a very good urologist, he was aware of all ideas and my supplements for my father and ok-ed it.

  2. [email protected]

    Dear Dr. Cannell,

    It is great to have such a source as the Vitamin D Council. Thank you for all your dedicated work. I truly appreciate your efforts.

    Rita Umile

Test Your Vitamin D Levels at Home!

Our in-home vitamin D test kit is easy, affordable, and an accurate way to find out your Vitamin D status.

order NOW

We need your help!

We're spreading awareness on Vitamin D Deficiency
Donate NOW
Latest Articles
4 tips for writing an essay in English

Writing an essay in English can be a challenge, especially if you are beginning to learn the language or do not yet fully master it. But don’t worry, did you know that there are strategies that can make this task easier for you? To help you meet this challenge, we leave you a series of […]

Weekly Newsletter

Our Sponsors

December 21st is DDAY. Click here to celebrate the day with us!