VDC test kit slider

Brazilian organization sets new guidelines for use of vitamin D in multiple sclerosis

Posted on: March 11, 2014   by  Vitamin D Council


The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology have released new guidelines and recommendations for neurologists caring for multiple sclerosis patients.

Multiple sclerosis (MS) is an autoimmune disease in which your own immune system attacks the nerves in the brain and spinal cord. This can lead to various symptoms all over the body including difficulties walking, talking, swallowing and thinking.

Vitamin D likely plays a role in multiple sclerosis. Past research has shown that those with low vitamin D levels are most likely to develop MS later in life. Researchers have also found that MS is more prevalent in places farther from the equator, where there is much less UVB, the spectrum that helps you make vitamin D.

The Scientific Department of Neuroimmunology (DCNI) of the Brazilian Academy of Neurology (ABN) met in September of 2013 to review the latest research in vitamin D and MS and help establish a set of guidelines on vitamin D for neurologists who care for people with MS.

Here are their recommendations and guidelines:

  1. Vitamin D shouldn’t be used as a sole treatment for MS. However, it can and should be used in conjunction with traditional medications.
  2. Vitamin D should be given to patients with MS regardless of the stage of disease.
  3. Vitamin D levels lower than 30 ng/ml should be corrected at any stage of MS.
  4. Patients should be prescribed their own vitamin D regimen based on their individual needs to reach vitamin D levels between 40 ng/ml and 100 ng/ml.
  5. Vitamin D levels should be determined and corrected in those with first signs of MS to help prevent conversion to MS.


Brum, D. G. et al. Supplementation and therapeutic use of vitamin Di n patients with multiple sclerosis: Consensus of the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology. Arquivos de Neuro-Psiquiatria, 2014.

11 Responses to Brazilian organization sets new guidelines for use of vitamin D in multiple sclerosis

  1. [email protected]

    Noted that the excellent work by Dr. Cicero Galli Coimbra (Brazil) is not mentioned at all.
    I suspect suspect that it is because he:
    1)Is not running a clinical trial – he apparently gives vitamin D to all of his MS patients
    2)Is not not giving a uniform dose to all of the patients – the dose ranges from 20,000 to 140,000 IU daily – whatever is needed for 150 ng level
    3)Is not giving the same amount co-factors to each patient
    4)Is using dietary restrictions to prevent patients from getting excess Calcium

    The entire paper and links to the great work in Brazil are at http://vitamindwiki.com/tiki-index.php?page_id=5155

  2. [email protected]

    Noted that six of eight points of consensus were “Grade D recommendations”, which may mean “against”. Has this been recognized in the summary given by the Council ?

  3. Jeff Nicklas


    Thanks for bringing that up. This team of researchers is not using the grading system of the USPSTF, which would mean a grade D level recommendation is “not recommended.” They’re likely using the grading system of the Centre for Evidence Based Medicine. Grade D recommendations in the CEBM scale recognizes that there is poor evidence for their recommendations, but their expert opinion endorses the treatment anyways.

    To see the CEBM’s grades, see here: http://www.cebm.net/?o=1025

    While there is more like grade B or C evidence for the use of vitamin D in MS in general, they likely rated their recommendations grade D because they get very specific with their recommendations, like to maintain a level of 40-100 ng/ml, which is primarily based on expert opinion, not study.

    Let me know if you have further questions or comments. Cheers, Jeff.

  4. Rita and Misty

    If I had MS, I would get my 25(OH)D level to 150 ng/ml, while working closely with an integrative medicine physician to monitor my blood calcium level. In my opinion there is much to gain and so very little to lose by trying this protocol. Actually, there is absolutely only gain possible via this method.

    I would want to be dancing when mainstream medicine finally catches a clue. 😉

  5. Ted

    Here is an interesting related observation. I recall that some studies show that sunshine works better for treating MS than supplemental vitamin D3. My son found this: dimethyl fumarate is an effective treatment for MS, according to wikipedia. And fumaric acid is produced in the skin by UV light. There may more to the sunlight story than just vitamin D.

  6. Rita and Misty


    There’s definitely a reason we were created to produce vitamin D via sunshine.

  7. IAW

    I like Wikipedia a lot and use it frequently. If I go there under fumaric acid it reads “Human skin naturally produces fumaric acid when exposed to sunlight.[citation needed]” Under citation needed is “To ensure that all Wikipedia content is verifiable, anyone may question an un-cited claim by inserting a {{Citation needed}} tag.” So someone has already questioned were this came from and is it a correct statement.

  8. [email protected]

    Hi Rita – Here’s a clue for you! MS is simply methanol poisoning, and should really be called “Methanol Syndrome”, all IMHO of course. 🙂

  9. Rita and Misty

    [email protected]

    A clue! Yes, recently I find myself painfully clueless 😉 Okay, back to serious stuff now.

    Methanol toxicity has been linked to autism, spina bifida, preterm delivery, MS and PD.

    However, I do wonder, if just like with lead poisoning, there is a vitamin D deficiency component at play.

    I wish I had the time to more deeply investigate the D connection. I do hope I will in the future, as all things D just simply fascinate me.

  10. Rogerio Luz Coelho

    But in the paper they point our that :

    Normal range

    The Institute of Medicine (IOM) and the American Society for Endocrinology advocate different levels of vitamin D to maintain bone health: ≥20 ng/ml and ≥30ng/ml, respectively 3 , 4 . There is no consensus on whether bone cells and immune cells require different levels of vitamin D. In addition to the lack of consensus on the normal range values for vitamin D, the toxic serum concentration and the concentration leading up to this condition are also controversial. In adults, doses greater than or equal to 10,000 IU/day are associated with hypercalcemia 31 , 32 .

    Shich seems to say they think 10.000 UI/d is associated with hypercalcemia … so people will have a hard time getting close to that 100 mg/mL level.

    I am Brazilian … and take 10.000 UI/d for more than a year … my 25-OH is at low 80’s.

    Cheers 🙂

  11. LauraM

    I’m treating 3 autoimmune conditions (Inflamatory Bowel Disease, Endometriosis and Hashimoto’s thyroiditis) with Dr. Cícero Galli Coimbra protocol. He’s been done a wonderful job for almost 11 years and now he’s treaning other physicians.
    I’m in touch with many of his pacients, most of them with Multiple Sclerosis, Crohn’s disease, Psoriasis, Vitiligo Ankylosing Spondylitis, Lupus erythematosus, Ulcerative colitis, Rheumatoid arthritis and they are very happy with the results, they live with no trace of their patologies.
    Vitamin D3 really “unplugs” autoimmune diseases and is a key hormone to our bodies functions. I hope soon the governmental agencies use this new findings about Vitamin D3 for the good of many, saving billions to the public health system.

Test Your Vitamin D Levels at Home!

Our in-home vitamin D test kit is easy, affordable, and an accurate way to find out your Vitamin D status.

order NOW

We need your help!

We're spreading awareness on Vitamin D Deficiency
Donate NOW
Latest Articles
4 tips for writing an essay in English

Writing an essay in English can be a challenge, especially if you are beginning to learn the language or do not yet fully master it. But don’t worry, did you know that there are strategies that can make this task easier for you? To help you meet this challenge, we leave you a series of […]

Weekly Newsletter

Our Sponsors

December 21st is DDAY. Click here to celebrate the day with us!