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Are different vitamin D levels needed to show an effect in different diseases?

Posted on: July 9, 2014   by  John Cannell, MD


In the latest paper from the Division of Health Sciences at the University of South Australia, Dr. Simon Spedding and colleagues reviewed the scientific literature to determine the relationship between vitamin D status and the role of vitamin D supplementation in the management of non-skeletal diseases. They found that different vitamin D levels may be needed to help prevent or treat different diseases.

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4 Responses to Are different vitamin D levels needed to show an effect in different diseases?

  1. Rita and Misty

    I often wonder if certain illnesses cause the body to use more vitamin D; and therefore, the body requires more vitamin D intake to remain healthy.

    I also wonder if 40 ng/ml, over a lifetime, would reduce the risk of cancer; but it would not be high enough to reduce the risk and/or treat cancer in folks who have been deficient for many (many) many years. Perhaps a much higher 25(OH)D level is required in these folks.

    I understand why researchers choose to study daily dose, in other words 3,000 iu D3 daily versus 1,000 iu D3 daily. But really, wouldn’t it be more accurate to study vitamin D blood levels? In other words, 50 ng/ml versus 25 ng/ml?

    These are just the musings of a lay(wo)man…I am not a physician, nor am I a scientific researcher. I just spend lots of time thinking about vitamin D.


  2. Magic


    I think this is what you and I have been trying to tell people for years. We have found this out because we had a problem that wasn’t going away. In your uncle and my wife they were huge problems.

    I am in touch with a lady who works in a doctor’s office in the town in Oregon where I grew up. I met her from this site. Her son was born with inaudible autism. He has been taking 20,000 international units of vitaminD3 for what is probably ten years now…He still is autistic but has a job and a life at 33 years of age now… and is much healthier. I mention this because It made me comfortable trying larger amounts. This is only one example, I have hundreds from studies on the internet and personal acquaintances..

    The University of Southern Australia study which brought out the example of baby aspirin not helping a headache like a migraine but an aspirin ten times stronger would help BINGO…

    Think of the money saved. Think of the lives made better. I haven’t been sick for decades.

    With all of the money going into healthcare we are 37th country in the world as far as being healthy. I am only 80, maybe I should go to south Australia to live…lol.

    No, seriously. we need to break the stronghold against anything that works. Can you believe the next move by the FDA may be a small 100 year test to see if D3 works over a lifetime. Then when it works they would test a larger group the same way….

  3. Rita and Misty

    Chutzpah πŸ™

  4. [email protected]

    This study, with the results summarized in a a single table has been on VitaminDWiki for 6 months now. http://vitamindwiki.com/tiki-index.php?page_id=4893.

    Here is the text of that table: in units of both nmol and ng
    Premature mortality Level 1 (Systematic Review) 75 nmol 30 ng
    Falls prevention Level 1 (Systematic Review) 95 nmol 38 ng
    Cancer prevention Level 2 (RCT) 100 nmol 40 ng
    Respiratory infection prevention Level 2 (RCT) 95 nmol 38 ng
    Diabetes prevention Level 2 (RCT) 80 nmol 32 ng
    Depression treatment Level 2 (RCT) 75 nmol 30 ng
    Musculoskeletal pain management Level 2 (RCT)
    Musculoskeletal strength Level 3-1 (Pseudo RCT)
    Dental disease Level 3-2 (Study with Controls) > 84nmol > 37 ng
    Cardiovascular disease Level 3-2 (Study with Controls) 80 nmol 32 ng
    Health service utilisation Level 3-2 (Study with Controls)

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