Research from Hepatology International found that in knockout mice with liver fibrosis, vitamin D deficiency results in a greater severity of the disease while vitamin D supplementation results in subsequent healing of the liver.
Liver fibrosis is characterized as the excessive accumulation of extracellular proteins, such as collagen, that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in liver scarring and liver failure, and often requires liver transplantation.
Vitamin D deficiency has been reported in 90% of patients with chronic liver diseases. Furthermore, in these patients, low vitamin D levels are associated with increased inflammation, a greater degree of fibrosis, and increased mortality risk.