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A look at the inconsistencies in research of vitamin D and inflammation

Posted on: January 3, 2014   by  John Cannell, MD

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Recently, headlines around the world reported that vitamin D does not work.

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1 Response to A look at the inconsistencies in research of vitamin D and inflammation

  1. EdwardHutchinson

    I like this paper “Vitamin D Inhibits Monocyte/macrophage Pro-inflammatory Cytokine Production by Targeting Mitogen-Activated Protein Kinase Phosphatase” Yong Zhang, Donald Y. M. Leung, and Elena Goleva” which shows how cells incubated in 30 ng/ml vitamin D and above showed significantly reduced response to the LPS. while the highest levels inhibition of inflammatory occurred at 50 ng/ml.
    That finding is consistent with this Fibromyalgia research The relation between vitamin D deficiency and fibromyalgia syndrome in women. 42 women showed a significant improvement when their blood level of 25(OH) D became>or=30 ng/mL, this improvement became more significant when their blood level of 25(OH) D exceeded 50 ng/ mL.
    Personally I think there may be a threshold effect as I found the greatest improvement in my chronic neuropathic pain came after I raised 25(OH)D above 100nmol/l, however, as I also increased magnesium intake at the same time it may have been that raising Vitamin D status in combination with improved magnesium status produced a more pronounced action than either alone.

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