Studies have suggested that vitamin D and vitamin K play may play a role in cardiovascular health. However, most research has investigated their effects on heart health separately, with little research available on the dual effect of vitamins D and K. Therefore, a recent study published in the journal Hypertension discovered that a combination of low vitamin D and K status was associated with higher systolic and diastolic blood pressure, as well as higher incidence of developing hypertension over time.
Researchers evaluated vitamin D and K status as well as systolic and diastolic blood pressure in 402 individuals. All individuals began the study without hypertension. Over the 6.4-year span, the researchers collected the incidence of those who developed high blood pressure in 231 patients.
This is what the researchers found:
- Low vitamin D and K (25(OH)D<20 ng/L and 323 pmol/L, respectively) was associated with an increased systolic 4.8 mm Hg and diastolic 3.1 mm Hg (P =0.013 for systolic blood pressure and 0.068 for diastolic blood pressure).
- 143 of the 231 patients (62%) without hypertension developed high blood pressure within 6.4 years.
“The combination of low vitamin D and K status was associated with increased blood pressure and might play a role in development of hypertension. Further prospective studies are needed to better understand the clinical implications of this relationship to promote cardiovascular health.”