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A combination of low vitamin D and vitamin K may play a role in increased blood pressure

Posted on: April 24, 2017   by  Vitamin D Council


Studies have suggested that vitamin D and vitamin K play may play a role in cardiovascular health. However, most research has investigated their effects on heart health separately, with little research available on the dual effect of vitamins D and K. Therefore, a recent study published in the journal Hypertension discovered that a combination of low vitamin D and K status was associated with higher systolic and diastolic blood pressure, as well as higher incidence of developing hypertension over time.

Researchers evaluated vitamin D and K status as well as systolic and diastolic blood pressure in 402 individuals. All individuals began the study without hypertension. Over the 6.4-year span, the researchers collected the incidence of those who developed high blood pressure in 231 patients.

This is what the researchers found:

  • Low vitamin D and K (25(OH)D<20 ng/L and 323 pmol/L, respectively) was associated with an increased systolic 4.8 mm Hg and diastolic 3.1 mm Hg (P =0.013 for systolic blood pressure and 0.068 for diastolic blood pressure).
  • 143 of the 231 patients (62%) without hypertension developed high blood pressure within 6.4 years.

Researchers concluded:

“The combination of low vitamin D and K status was associated with increased blood pressure and might play a role in development of hypertension. Further prospective studies are needed to better understand the clinical implications of this relationship to promote cardiovascular health.”


Van Ballegooijen, A. Joint Association of Low Vitamin D and Vitamin K Status with Blood Pressure and Hypertension. Hypertension, 2017.

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