Vitamin D Products

(off-site)

Donate via PayPal

Your tax-deductable gift will help us to be more effective in our mission to end the worldwide epidemic of vitamin D deficiency.

Vitamin D On The Web

See our Vitamin D News page for all the latest vitamin D headlines from around the globe.

Our Best Vitamin D Articles page for links to informative, less-mainstream articles on vitamin D and UV exposure.

Vitamin D Research

back to research menu

Genetics

Vitamin D Receptor Gene ApaI Polymorphism Is Associated with Susceptibility to Colorectal Cancer. Dig Dis Sci. 2009 Oct 1.
Hereditary vitamin D resistant rickets: identification of a novel splice site mutation in the vitamin D receptor gene and successful treatment with oral calcium therapy. Bone. 2009 Oct;45(4):743–6.
Evidence of association of Vitamin D receptor Apa I gene polymorphism with bone mineral density in postmenopausal women with osteoporosis. Clin Rheumatol. 2009 Oct;28(10):1187–91.
No association between vitamin D receptor polymorphisms and coronary artery disease in a Chinese population. DNA Cell Biol. 2009 Oct;28(10):521–5.
MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab Dispos. 2009 Oct;37(10):2112–7.
Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor. Nephrol Dial Transplant. 2009 Oct;24(10):3006–12.
The Basic Helix-loop-helix Proteins DEC1 and DEC2 Function as Corepressors of Retinoid X Receptors. Mol Pharmacol. 2009 Sep 28.
A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy. Nephrol Dial Transplant. 2009 Sep 27.
p73 is essential for vitamin D-mediated osteoblastic differentiation. Cell Death Differ. 2009 Sep 25.
Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Am J Physiol Gastrointest Liver Physiol. 2009 Sep 24.
Understanding and Determining the Etiology of Autism. Cell Mol Neurobiol. 2009 Sep 23.
The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development. Dev Biol. 2009 Sep 23.
Phosphorylation of WSTF by MAPK induces a switching between two distinct chromatin remodeling complexes. J Biol Chem. 2009 Sep 23.
Compensatory induction of the TRPV6 channel in a calbindin-D9k knockout mouse: Its regulation by 1,25-hydroxyvitamin D(3). J Cell Biochem. 2009 Sep 23.
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231–43.
Protein Kinase C-Dependent Upregulation of miR-203 Induces the Differentiation of Human Keratinocytes. J Invest Dermatol. 2009 Sep 17.
Vitamin D receptor gene FokI polymorphisms influence bone mass in adolescent football (soccer) players. Eur J Appl Physiol. 2009 Sep 16.
Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer. J Nutr. 2009 Sep 16.
MicroRNA regulates human vitamin D receptor. Int J Cancer. 2009 Sep 15;125(6):1328–33.
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. Anticancer Res. 2009 Sep;29(9):3511–36. Review.
Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals. Mol Carcinog. 2009 Aug;48(8):758–72.
The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin. Dev Comp Immunol. 2009 Aug;33(8):901–12.
Vitamin D Receptor Gene Polymorphisms Modulate The Skeletal Response to Vitamin D Supplementation in Healthy Girls. Bone. 2009 Jul 29.
Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS). Osteoporos Int. 2009 Jul 24.
Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica. Biochem Biophys Res Commun. 2009 Jul 24;385(2):170–5.
Premature aging in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol. 2009 Jul;115(3–5):91–7.
Hypophosphatasia may lead to bone fragility: don't miss it. Eur J Pediatr. 2009 Jul;168(7):783–8.
In vitro culture and differentiation of osteoblasts from human umbilical cord blood. Cell Tissue Bank. 2009 Jun 30.
Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent Twins. J Clin Endocrinol Metab. 2009 Jun 23.
Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families. Osteoporos Int. 2009 Jun 19.
Genetic variation in the vitamin D receptor and polycystic ovary syndrome risk. Fertil Steril. 2009 Jun 5.
Nuclear receptors: genomic and non-genomic effects converge. Cell Cycle. 2009 Jun 1;8(11):1675–80.
Vitamin D receptor gene polymorphisms and Graves' disease: a meta-analysis. Clin Endocrinol (Oxf). 2009 Jun;70(6):938–45.
Vitamin D receptor variants and breast cancer risk in the Polish population. Breast Cancer Res Treat. 2009 Jun;115(3):629–33.
Multiple sclerosis and the major histocompatibility complex. Curr Opin Neurol. 2009 Jun;22(3):219–25.
Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. Endocrinology. 2009 Jun;150(6):2543–50.
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin. FASEB J. 2009 Jun;23(6):1643–54.
The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain. Mol Cell Biol. 2009 Jun;29(11):3045–61.
Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem. 2009 May 29;284(22):14838–48.
Treatment of K562 cells with 1,25-dihydroxyvitamin D(3) induces distinct alterations in the expression of apoptosis-related genes BCL2, BAX, BCL(XL), and p21. Ann Hematol. 2009 May 28.
A new axis of phosphate balance control: Fibroblast Growth Factor 23-Klotho. Nephrol Ther. 2009 May 21.
Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol. J Immunol. 2009 May 15;182(10):6071–8.
1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway. Am J Physiol Renal Physiol. 2009 May;296(5):F1212–8.
Vitamin D-related Genes, Serum Vitamin D Concentrations, and Prostate Cancer Risk. Carcinogenesis. 2009 May;30(5):769–76.
Initial FGF23-mediated signaling occurs in the distal convoluted tubule. J Am Soc Nephrol. 2009 May;20(5):955–60.
Unusually severe phenotype of neonatal primary hyperparathyroidism due to a heterozygous inactivating mutation in the CASR gene. Eur J Pediatr. 2009 May;168(5):569–73.
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3. J Med Chem. 2009 Apr 23;52(8):2204–13.
Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. Circ Res. 2009 Apr 10;104(7):851–9.
The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways. Prostate. 2009 Apr 1;69(5):480–93.
Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice. Gastroenterology. 2009 Apr;136(4):1317–27, e1–2.
Different enamel and dentin mineralization observed in VDR deficient mouse model. Arch Oral Biol. 2009 Apr;54(4):299–305.
Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2. J Cell Physiol. 2009 Apr;219(1):132–42.
Vitamin D and Melanoma. Ann Epidemiol. 2009 Mar 10.
Endocrine controls of keratin expression. Bioessays. 2009 Mar 9.
Impact of vitamin D receptor activity on experimental autoimmune prostatitis. J Autoimmun. 2009 Mar 6.
Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas. J Bone Miner Metab. 2009 Mar 3.
Calcium-Sensing Receptor Expression is Regulated by Glial Cells Missing-2 in Human Parathyroid Cells. J Bone Miner Res. 2009 Mar 3.
Polymorphisms in the vitamin D receptor and risk of ovarian cancer in four studies. Cancer Res. 2009 Mar 1;69(5):1885–91.
Vitamin D metabolism and vitamin D traditional and nontraditional, target organs: implications for kidney patients. J Ren Care. 2009 Mar;35 Suppl 1:39–44.
5' regulatory and 3' untranslated region polymorphisms of vitamin D receptor gene in south Indian HIV and HIV-TB patients. J Clin Immunol. 2009 Mar;29(2):196–204.
Direct upregulation of parathyroid calcium-sensing receptor and vitamin D receptor by calcimimetics in uremic rats. Am J Physiol Renal Physiol. 2009 Mar;296(3):F605–13.
Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells. Carcinogenesis. 2009 Mar;30(3):449–56.
Vitamin D receptor gene polymorphisms and the risk of colorectal cancer in a Chinese population. Dig Dis Sci. 2009 Mar;54(3):634–9.
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. Drug Metab Dispos. 2009 Mar;37(3):469–78.
Presence of 25(OH)D deficiency and its effect on vitamin D receptor mRNA expression. Eur J Clin Nutr. 2009 Mar;63(3):446–9.
Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility. Genes Immun. 2009 Mar;10(2):174–80.
Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus. Histochem Cell Biol. 2009 Mar;131(3):365–70.
Plasma 1,25 Dihydroxy Vitamin D(3) Level and Expression of Vitamin D Receptor and Cathelicidin in Pulmonary Tuberculosis. J Clin Immunol. 2009 Feb 14.
CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells-comparison with other conazole pesticides. Toxicol Lett. 2009 Feb 10;184(3):159–68.
Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis. Exp Mol Pathol. 2009 Feb;86(1):69–73.
Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009 Jan;94(1):26–34. Review.
Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model. Bone. 2009 Jan;44(1):32–45.
Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: The 'Power Rehabilitation' program. Int J Mol Med. 2009 Jan;23(1):81–8.
Analysis of CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, as a candidate tumor suppressor gene in primary and severe secondary/tertiary hyperparathyroidism. J Bone Miner Res. 2009 Jan;24(1):102–4.
The effect of differentiation on 1,25 dihydroxyvitamin D-mediated gene expression in the enterocyte-like cell line, Caco-2. J Cell Physiol. 2009 Jan;218(1):113–21.
1,25-Dihydroxy vitamin D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60-activated matrix vesicle matrix metalloproteinases. Cells Tissues Organs. 2009;189(1–4):70–4.
Dentin noncollagenous matrix proteins in familial hypophosphatemic rickets. Cells Tissues Organs. 2009;189(1–4):219–23.
Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells. Endocrine. 2008 Dec 31.
Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20834–9.
Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies. BMC Cancer. 2008 Dec 23;8(1):385.
Circulating 25-Hydroxyvitamin D, VDR Polymorphisms, and Survival in Advanced Non-Small-Cell Lung Cancer. J Clin Oncol. 2008 Dec 1;26(34):5596–602.
Association of vitamin D receptor gene polymorphisms in Iranian patients with inflammatory bowel disease. J Gastroenterol Hepatol. 2008 Dec;23(12):1816–22.
Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney Int. 2008 Dec;74(11):1394–402.
Expression of the vitamin d receptor is increased in the hypertrophic heart. Hypertension. 2008 Dec;52(6):1106–12.
The vitamin D deficiency pandemic and consequences for nonskeletal health: Mechanisms of action. Mol Aspects Med. 2008 Dec;29(6):361–8. Review.
Loss of vitamin d receptor produces polyuria by increasing thirst. J Am Soc Nephrol. 2008 Dec;19(12):2396–405.
Association of Genetic Polymorphisms in Vitamin D Receptor Gene and Susceptibility to Sporadic Prostate Cancer. Exp Biol Med (Maywood). 2008 Dec;233(12):1608–14.
Vitamin D Receptor Genotype in Hypophosphatemic Rickets as a Predictor of Growth and Response to Treatment. J Clin Endocrinol Metab. 2008 Dec;93(12):4672–82.
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. J Cell Biol. 2008 Nov 17;183(4):697–710.
Vitamin D receptor polymorphisms and the risk of cutaneous melanoma: a systematic review and meta-analysis. Cancer. 2008 Nov 1;113(9):2398–407.
Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Int J Cancer. 2008 Nov 1;123(9):2170–9.
A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression. J Steroid Biochem Mol Biol. 2008 Nov;112(1–3):47–54.
Superagonistic fluorinated vitamin d(3) analogs stabilize helix 12 of the vitamin d receptor. Chem Biol. 2008 Oct 20;15(10):1029–34.
Functional gene polymorphisms in canadian aboriginal populations with high rates of tuberculosis. J Infect Dis. 2008 Oct 15;198(8):1175–9.
HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. Cancer Biol Ther. 2008 Oct 7;7(10).
Inactivation of the Human Vitamin D Receptor by Caspase-3. Endocrinology. 2008 Oct 1.
Genetic variation in calcium-sensing receptor and risk for colon cancer. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2755–65.
Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008 Oct;29(6):726–76. Review.
Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis. J Invest Dermatol. 2008 Oct;128(10):2508–17.
Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway. J Cell Biochem. 2008 Sep 2;105(4):980–988.
Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome. Aging Male. 2008 Sep;11(3):134–9.
The vitamin D receptor gene BsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women. Gynecol Endocrinol. 2008 Sep;24(9):514–8.
Polymorphisms of the VDR gene are associated with presence of solar keratoses on the skin. Br J Dermatol. 2008 Sep;159(4):804–10.
Association of vitamin D receptor gene variants, adiposity and colon cancer. Carcinogenesis. 2008 Sep;29(9):1788–93.
20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation. J Invest Dermatol. 2008 Sep;128(9):2271–80.
The vitamin D receptor Fok1 polymorphism and bone mineral density in Chinese children. Clin Chim Acta. 2008 Sep;395(1–2):111–4.
Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 2008 Sep;93(9):3381–8.
Identification of the functional vitamin D response elements in the human MDR1 gene. Biochem Pharmacol. 2008 Aug 15;76(4):531–42.
Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. J Bone Miner Res. 2008 Aug;23(8):1249–56.
Regulatory role of promoter and 3' UTR variants of vitamin D receptor gene on cytokine response in pulmonary tuberculosis. J Clin Immunol. 2008 Jul;28(4):306–13.
Molecular aspects of osteopathy in type 1 Gaucher disease: correlation between genetics and bone density. Rheumatol Int. 2008 Jul;28(9):873–7.
Enriched uranium affects the expression of vitamin D receptor and retinoid X receptor in rat kidney. J Steroid Biochem Mol Biol. 2008 Jun;110(3–5):263–8.
Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. J Invest Dermatol. 2008 Apr;128(4):816–24.
Exclusion of COL2A1 and VDR as developmental dysplasia of the hip genes. Clin Orthop Relat Res. 2008 Apr;466(4):878–83.
Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population. Int J Immunogenet. 2008 Apr;35(2):125–31.
Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population. Hum Immunol. 2008 Feb;69(2):134–8.
Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response. J Bone Miner Res. 2007 Dec;22 Suppl 2:V20–4. Review.
Vitamin D: molecular mechanism of action. Ann N Y Acad Sci. 2007 Nov;1116:340–8. Review.
Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo. J Biol Chem. 2007 Aug 3;282(31):22344–52.
Expanding role for vitamin D in chronic kidney disease: importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha,25-dihydroxyvitamin D(3). Semin Dial. 2007 Jul;20(4):316–324.
Identification and functional characterization of a novel mutation in the calcium-sensing receptor gene in familial hypocalciuric hypercalcemia: modulation of clinical severity by vitamin D status. J Clin Endocrinol Metab. 2007 Jul;92(7):2616–23.
What is new in vitamin D: 2006–2007. Curr Opin Rheumatol. 2007 Jul;19(4):383–8.
Lithocholic acid can carry out in vivo functions of vitamin D. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10006–9.
Activation of the human immunodeficiency virus type I long terminal repeat by 1alpha,25-dihydroxyvitamin D3. J Mol Endocrinol. 2007 Jun;38(6):587–601.
Cholecalciferol significantly increases 25-hydroxyvitamin D concentrations in adults with cystic fibrosis. Am J Clin Nutr. 2007 May;85(5):1307–11.
Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol. 2007 May;104(3–5):274–80.
Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytes. J Biol Chem. 2007 Apr 13;282(15):10953–62.
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest. 2007 Mar;117(3):803–11.
Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. BMC Immunol. 2007 Mar 30;8:5.
Enhancers located in the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 2007 Mar;103(3–5):435–9.
A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer. PLoS Med. 2007 Mar;4(3):e103.
Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells. Mol Immunol. 2007 Mar;44(8):2107–14.
Drug insight: vitamin D analogs in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. Nat Clin Pract Endocrinol Metab. 2007 Feb;3(2):134–44. Review.
In vivo effects of chronic contamination with depleted uranium on vitamin D(3) metabolism in rat. Biochim Biophys Acta. 2007 Feb;1770(2):266–72.
Age-related alteration of 1alpha,25(OH)(2)-vitamin D (3)-dependent activation of p38 MAPK in rat intestinal cells. Biogerontology. 2007 Feb;8(1):13–24.
1,25-Dihydroxyvitamin D(3) regulates genes responsible for detoxification in intestine. Toxicol Appl Pharmacol. 2007 Jan 1;218(1):37–44.
The genetic background of osteoporosis in cystic fibrosis: association analysis with polymorphic markers in four candidate genes. J Cyst Fibros. 2006 Dec;5(4):229–35.
Mutational analysis of the vitamin D receptor does not support its candidacy as a tumor suppressor gene in parathyroid adenomas. J Clin Endocrinol Metab. 2006 Dec;91(12):5019–21.
Vitamin d receptor: new assignments for an already busy receptor. Endocrinology. 2006 Dec;147(12):5542–8.
Effects of 25-Hydroxyvitamin D3 and 1,25-Dihydroxyvitamin D3 on Cytokine Production by Human Decidual Cells. Biol Reprod. 2006 Dec;75(6):816–22.
Distinct association of gene polymorphisms of estrogen receptor and vitamin D receptor with lumbar spondylosis in post-menopausal women. Eur Spine J. 2006 Oct;15(10):1521–8.
Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta. 2006 Oct;372(1–2):33–42.
Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849–56.
Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies. Hum Mol Genet. 2006 Sep 15;15(18):2772–83.
Vitamin D physiology. Prog Biophys Mol Biol. 2006 Sep;92(1):4–8. Review.
Vitamin D and its role in immunology: Multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol. 2006 Sep;92(1):60–4. Review.
Chronic contamination with 137Cesium affects Vitamin D3 metabolism in rats. Toxicology. 2006 Aug 1;225(1):75–80.
Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat. Arch Toxicol. 2006 Aug;80(8):473–480.
Vitamin D metabolism in peripheral blood mononuclear cells is influenced by chewing "betel nut" (Areca catechu) and vitamin D status. J Clin Endocrinol Metab. 2006 Jul;91(7):2612–7.
Recent studies on vitamin D metabolizing enzymes. Clin Calcium. 2006 Jul;16(7):1129–35. Review.
1alpha,25(OH)(2)-Vitamin D(3) stimulates intestinal cell p38 MAPK activity and increases c-Fos expression. Int J Biochem Cell Biol. 2006 Jul;38(7):1181–90.
Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3. Mol Endocrinol. 2006 Jun;20(6):1231–47.
Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest. 2006 Jun;116(6):1703–12.
Association between vitamin D receptor, CCR5, TNF-alpha and TNF-beta gene polymorphisms and HBV infection and severity of liver disease. J Hepatol. 2006 May;44(5):856–63.
Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. Arch Toxicol. 2006 Apr;80(4):187–95.
Programmed cell death of stressed keratinocytes and its inhibition by vitamin D: The role of death and survival signaling pathways. Apoptosis. 2006 Apr;11(4):519–34.
1,25-Dihydroxyvitamin D3 inhibits tumor necrosis factor-alpha-induced adhesion molecule expression in endothelial cells. Cell Biol Int. 2006 Apr;30(4):365–75.
Vitamin D signaling is modulated on multiple levels in health and disease. Mol Cell Endocrinol. 2006 Mar 27;248(1–2):149–59. Review.
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24;311(5768):1770–3.
Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia J Clin Invest. 116:1703–1712 (2006) March.
Cardiovascular disease in chronic kidney failure: the role of VDR activators. Curr Opin Investig Drugs. 2006 Mar;7(3):206–13. Review.
Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene. Neurosci Lett. 2006 Feb 6;394(1):69–73.
Genetic markers in the pathogenesis of osteopenia and osteoporosis in cystic fibrosis. Med Wieku Rozwoj. 2006 Jan–Mar;10(1 Pt 2):275–87. Review.
Recent advances in the genetics of osteoporosis. J Musculoskelet Neuronal Interact. 2006 Jan–Mar;6(1):27–35. Review.
Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes. J Bone Miner Res. 2006 Jan;21(1):37–47.
New insights into mineral and skeletal regulation by active forms of vitamin D. Kidney Int. 2006 Jan;69(2):218–23. Review.
Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency. Curr Med Chem. 2006;13(24):2857–73. Review.
Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women. Arthritis Res Ther. 2006;8(1):R20.
Genetic Ablation of Vitamin D Activation Pathway Reverses Biochemical and Skeletal Anomalies in Fgf-23-Null Animals. American Journal of Pathology. 2006;169:2161–2170.
Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol. 2005 Oct;97(1–2):93–101. Review.
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3 FASEB J. 2005 Jul;19(9):1067–77.
Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. J Biol Chem. 2005 May 27;280(21):20604–11.
Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases. Neurosci Lett. 2005 May 20–27;380(1–2):37–41.
Vitamin-D receptor (VDR) gene (Fok-I, Taq-I and Apa-I) polymorphisms in healthy individuals from north Indian population. Asian Pac J Cancer Prev. 2005 Apr–Jun;6(2):147–52.
1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. J Bone Miner Res. 2005 Feb;20(2):305–17.
Intervention in autoimmunity: the potential of vitamin D receptor agonists. Cell Immunol. 2005 Feb;233(2):115–24. Review.
Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse. Endocrinology. 2005 Feb;146(2):825–34.
Vitamin D: a hormone for all seasons—how much is enough? Clin Biochem Rev. 2005 Feb;26(1):21–32.
Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005 Jan 1;10:119–34. Review.
Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol. 2005 Jan;35(1):217–24.
Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004 Sep 1;338(2):143–56. Review.
Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands. J Steroid Biochem Mol Biol. 2004 May;89–90(1–5):437–41. Review.
1alpha,25-dihydroxyvitamin D3 inducible transcription factor and its role in the vitamin D action. Endocr Regul. 2004 Mar;38(1):29–38. Review.
Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst. 2003 Dec 3;95(23):1765–71.
A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol. 2003 Dec;17(12):2386–92.
2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts. J Biol Chem. 2003 Aug 22;278(34):31756–65.
Altered gene expression profile in the kidney of vitamin D receptor knockout mice. J Cell Biochem. 2003 Jul 1;89(4):709–19.
Metabolism of 26,26,26,27,27,27-F6-1alpha,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats. Biochem Pharmacol. 2003 Jun 15;65(12):1957–65.
Rescue of the pseudo-vitamin D deficiency rickets phenotype of CYP27B1-deficient mice by treatment with 1,25-dihydroxyvitamin D3: biochemical, histomorphometric, and biomechanical analyses. J Bone Miner Res. 2003 Apr;18(4):637–43.
New insights into the mechanisms of vitamin D action. J Cell Biochem. 2003 Mar 1;88(4):695–705. Review.
The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand). 2003 Mar;49(2):277–300. Review.
Interleukin-2 is one of the targets of 1,25-dihydroxyvitamin D3 in the immune system. Arch Biochem Biophys. 2002 Jun 15;402(2):249–54.
CD8(+) T cells are not necessary for 1 alpha,25-dihydroxyvitamin D(3) to suppress experimental autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5557–60.
Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D. Cancer Epidemiol Biomarkers Prev. 2002 Jan;11(1):113–9.
Rag-1-dependent cells are necessary for 1,25-dihydroxyvitamin D(3) prevention of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2001 Sep 3;119(1):16–29.
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression. Biochem Biophys Res Commun. 2001 Jul 27;285(4):1012–7.
Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7498–503.
Micronutrient accumulation and depletion in schizophrenia, epilepsy, autism and Parkinson's disease? Med Hypotheses. 2001 May;56(5):641–5.
Vitamin D and genomic stability. Mutat Res. 2001 Apr 18;475(1–2):69–87. Review.
Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form (review). Int J Mol Med. 2001 Feb;7(2):201–9. Review.
25-hydroxyvitamin D 1alpha-hydroxylase: structure of the mouse gene, chromosomal assignment, and developmental expression. J Bone Miner Res. 2001 Jan;16(1):46–56.
Human genetics: lessons from Quebec populations. Annu Rev Genomics Hum Genet. 2001;2:69–101. Review.
Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24). Biotechnol Annu Rev. 2001;7:179–94. Review.
Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24. Eur J Biochem. 2000 Oct;267(20):6158–65.
Human 25-hydroxyvitamin D-1alpha-hydroxylase: cloning, mutations, and gene expression. Pediatr Nephrol. 2000 Jul;14(7):620–5. Review.
An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. J Nutr Biochem. 2000 May;11(5):267–72.
Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Canadian Collaborative Study Group. Neurology. 2000 Feb 8;54(3):729–32.
Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor. J Cell Biochem. 1999 Dec 1;75(3):462–80.
Genetic mutation in the human 25-hydroxyvitamin D3 1alpha-hydroxylase gene causes vitamin D-dependent rickets type I. Mol Cell Endocrinol. 1999 Oct 25;156(1–2):7–12. Review.
The renal function of 25-hydroxyvitamin D3-1alpha-hydroxylase. Mol Cell Endocrinol. 1999 May 25;151(1–2):213–20. Review.
Novel mutations in the 1alpha-hydroxylase (P450c1) gene in three families with pseudovitamin D-deficiency rickets resulting in loss of functional enzyme activity in blood-derived macrophages. J Bone Miner Res. 1999 May;14(5):730–9.
20-Cyclopropyl-cholecalciferol vitamin D3 analogs: a unique class of potent inhibitors of proliferation of human prostate, breast and myeloid leukemia cell lines. Anticancer Res. 1999 May–Jun;19(3A):1689–97.
In vivo function of VDR in gene expression-VDR knock-out mice. J Steroid Biochem Mol Biol. 1999 Apr–Jun;69(1–6):247–51. Review.
Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families. Am J Hum Genet. 1998 Dec;63(6):1694–702.
Two novel 1alpha-hydroxylase mutations in French-Canadians with vitamin D dependency rickets type I1. Kidney Int. 1998 Nov;54(5):1437–43.
Thyroid hormone receptor does not heterodimerize with the vitamin D receptor but represses vitamin D receptor-mediated transactivation. Mol Endocrinol. 1998 Sep;12(9):1367–79.
Mechanisms and functions of vitamin D. Nutr Rev. 1998 Feb;56(2 Pt 2):S4–10; discussion S 54–75. Review.
Molecular cloning of (25-OH D)-1 alpha-hydroxylase: an approach to the understanding of vitamin D pseudo-deficiency. Recent Prog Horm Res. 1998;53:341–9; discussion 350.
Complete structure of the human gene for the vitamin D 1alpha-hydroxylase, P450c1alpha. DNA Cell Biol. 1997 Dec;16(12):1499–507.
The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. J Bone Miner Res. 1997 Oct;12(10):1552–9.
The vitamin D hormone and its nuclear receptor: molecular actions and disease states. J Endocrinol. 1997 Sep;154 Suppl:S57–73. Review.
Vitamin D metabolism in human colon adenocarcinoma-derived Caco-2 cells: expression of 25-hydroxyvitamin D3-1alpha-hydroxylase activity and regulation of side-chain metabolism. J Steroid Biochem Mol Biol. 1997 May;62(1):21–8.
Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3. Biochem J. 1996 Jun 1;316 ( Pt 2):361–71. Review.
Antagonistic effects of transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements. Endocrinology. 1996 May;137(5):2001–11.
Stable expression of the nuclear vitamin D receptor in the human prostatic carcinoma cell line JCA-1: evidence that the antiproliferative effects of 1 alpha, 25-dihydroxyvitamin D3 are mediated exclusively through the genomic signaling pathway. Endocrinology. 1996 May;137(5):1554–61.
Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo. Mol Cell Biol. 1996 Mar;16(3):1006–16.
New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone. 1995 Aug;17(2 Suppl):33S–38S. Review.
Receptor mediated genomic action of the 1,25(OH)2D3 hormone: expression of the human vitamin D receptor in E. coli. J Steroid Biochem Mol Biol. 1995 Jun;53(1–6):583–94.
Genomic actions of 1,25-dihydroxyvitamin D3. J Nutr. 1995 Jun;125(6 Suppl):1690S–1694S. Review.
Natural vitamin D3 response elements formed by inverted palindromes: polarity-directed ligand sensitivity of vitamin D3 receptor-retinoid X receptor heterodimer-mediated transactivation. Mol Cell Biol. 1995 Mar;15(3):1154–61.
Potent vitamin D3 analogs: their abilities to enhance transactivation and to bind to the vitamin D3 response element. Leuk Res. 1995 Mar;19(3):147–58.
Single-dose cholecalciferol suppresses the winter increase in parathyroid hormone concentrations in healthy older men and women: a randomized trial. Am J Clin Nutr. 1994 May;59(5):1040–4.
Regulation of metallothionein gene expression by 1 alpha,25-dihydroxyvitamin D3 in cultured cells and in mice. Proc Natl Acad Sci U S A. 1987 Dec;84(24):8810–3.
1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production of the monokine, mononuclear cell factor. J Clin Invest. 1984 Mar;73(3):731–9.
Osteoporosis and osteomalacia. Schweiz Med Wochenschr. 1975 Apr 12;105(15):466–70.
Chromosomal receptor for a vitamin D metabolite. Proc Natl Acad Sci U S A. 1969 Jan;62(1):155–62.

back to research menu

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Unless otherwise expressly stated, all site content licensed under a Creative Commons License.