Vitamin D Research

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Physiology

• Characterizing Early Events Associated with the Activation of Target Genes by 1,25‑Dihydroxyvitamin D3 in Mouse Kidney and Intestine in VivoJ Biol Chem. Vol. 282, Issue 31, 22344–22352, August 3, 2007.
• Modulatory effects of 1,25‑dihydroxyvitamin d3 on human B cell differentiation.J Immunol. 2007 Aug 1;179(3):1634–47.
• What is new in vitamin D: 2006–2007.Curr Opin Rheumatol. 2007 Jul;19(4):383–8.
• Lithocholic acid can carry out in vivo functions of vitamin D.Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10006–9. Epub 2007 May 29.
• Activation of the human immunodeficiency virus type I long terminal repeat by 1alpha,25‑dihydroxyvitamin D3.J Mol Endocrinol. 2007 Jun;38(6):587–601.
• A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer. PLoS Med. 2007 March 20;4(3): e103.
• Upregulation of Vitamin D binding protein (Gc‑globulin) binding sites during neutrophil activation from a latent reservoir in azurophil granules.Mol Immunol. 2007 Mar;44(9):2370–7. Epub 2006 Nov 20.
• Role of nuclear hormone receptors in butyrate‑mediated up‑regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells. Molecular Immunology Volume 44, Issue 8, March 2007, Pages 2107–2114.
• In vivo relevance for photoprotection by the vitamin D rapid response pathway.J Steroid Biochem Mol Biol. 2007 Jan 11;.
• 1,25‑Dihydroxyvitamin D(3) regulates genes responsible for detoxification in intestine.Toxicol Appl Pharmacol. 2007 Jan 1;218(1):37–44. Epub 2006 Oct 13.
• Mutational Analysis of the Vitamin D Receptor Does Not Support Its Candidacy as a Tumor Suppressor Gene in Parathyroid Adenomas.Journal of Clinical Endocrinology & Metabolism Vol. 91, No. 12 5019–5021.
• Genetic Ablation of Vitamin D Activation Pathway Reverses Biochemical and Skeletal Anomalies in Fgf‑23‑Null Animals.American Journal of Pathology. 2006;169:2161–2170.
• Vitamin d receptor: new assignments for an already busy receptor.Endocrinology. 2006 Dec;147(12):5542–8. Epub 2006 Aug 31.
• Biological and clinical aspects of the vitamin D binding protein (Gc‑globulin) and its polymorphism.Clin Chim Acta. 2006 Oct;372(1–2):33–42. Epub 2006 May 12.
• Characterization of rat and human CYP2J enzymes as Vitamin D 25‑hydroxylases.Steroids. 2006 Oct;71(10):849–56. Epub 2006 Jul 13.
• Effects of 25‑Hydroxyvitamin D3 and 1,25‑Dihydroxyvitamin D3 on Cytokine Production by Human Decidual Cells.Biol Reprod. 2006 Sep 6;
• Vitamin D physiology.Prog Biophys Mol Biol. 2006 Sep;92(1):4–8. Epub 2006 Feb 28. Review.
• 1alpha,25(OH)(2)‑Vitamin D(3) stimulates intestinal cell p38 MAPK activity and increases c‑Fos expression.Int J Biochem Cell Biol. 2006 Jul;38(7):1181–90. Epub 2006 Jan 24.
• Cardiovascular disease in chronic kidney failure: the role of VDR activators.Curr Opin Investig Drugs. 2006 Mar;7(3):206–13. Review.
• 24,25‑dihydroxyvitamin D(3) binds to catalase.J Cell Biochem. 2006 Mar 21;97(6):1259–1266
• Programmed cell death of stressed keratinocytes and its inhibition by vitamin D: The role of death and survival signaling pathways.Apoptosis. 2006 Mar 9;
• Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug‑induced osteomalacia.J. Clin. Invest. 116:1703–1712 (2006) March.
• Vitamin D signaling is modulated on multiple levels in health and disease.Mol Cell Endocrinol. 2006 Mar 27;248(1–2):149–59. Epub 2006 Jan 9. Review.
• New insights into mineral and skeletal regulation by active forms of vitamin D.Kidney Int. 2006 Jan;69(2):218–23. Review.
• Altered pharmacokinetics of 1alpha,25‑dihydroxyvitamin D3 and 25‑hydroxyvitamin D3 in the blood and tissues of the 25‑hydroxyvitamin D‑24‑hydroxylase (Cyp24a1) null mouse.Endocrinology. 2005 Feb;146(2):825–34. Epub 2004 Oct 21.
• Vitamin D: a hormone for all seasons—how much is enough?Clin Biochem Rev. 2005 Feb;26(1):21–32.
• Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‑regulated in myeloid cells by 1,25‑dihydroxyvitamin D3FASEB. 2005;19:1067–1077.
• Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans.Journal of Clinical Endocrinology & Metabolism 2004 Aug Vol. 89, No. 11 5387–5391.
• Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients.Nutr J. 2004 Jul 19;3:8.
• Vitamin D in preventive medicine: are we ignoring the evidence?Br J Nutr. 2003 May;89(5):552–72. Review.
• Vitamin D: A millenium perspective.J Cell Biochem. 2003 Feb 1;88(2):296–307. Review.
• Evolution and function of vitamin D.Recent Results Cancer Res. 2003;164:3–28. Review.
• Vitamin D insufficiency: no recommended dietary allowance exists for this nutrient.CMAJ. 2002 Jun 11;166(12):1541–2. Comment.
• Vitamin D and genomic stability.Mutat Res. 2001 Apr 18;475(1–2):69–87. Review.
• Calcium and vitamin D. Diagnostics and therapeutics.Clin Lab Med. 2000 Sep;20(3):569–90. Review.
• An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3.J Nutr Biochem. 2000 May;11(5):267–72.
• Evidence that vitamin D3 increases serum 25‑hydroxyvitamin D more efficiently than does vitamin D2.Am J Clin Nutr. 1998 Oct;68(4):854–8.
• Mechanisms and functions of vitamin D.Nutr Rev. 1998 Feb;56(2 Pt 2):S4–10; discussion S 54–75. Review.
• Calcium absorptive effects of vitamin D and its major metabolites.J Clin Endocrinol Metab. 1997 Dec;82(12):4111–6.
• Vitamin D metabolism in human colon adenocarcinoma‑derived Caco‑2 cells: expression of 25‑hydroxyvitamin D3‑1alpha‑hydroxylase activity and regulation of side‑chain metabolism.J Steroid Biochem Mol Biol. 1997 May;62(1):21–8.
• Bioavailability of vitamin D.Eur J Clin Nutr. 1997 Jan;51 Suppl 1:S76–9. Review.
• The effect of season and latitude on in vitro vitamin D formation by sunlight in South Africa.S Afr Med J. 1996 Oct;86(10):1270–2.
• Stable expression of the nuclear vitamin D receptor in the human prostatic carcinoma cell line JCA‑1: evidence that the antiproliferative effects of 1 alpha, 25‑dihydroxyvitamin D3 are mediated exclusively through the genomic signaling pathway.Endocrinology. 1996 May;137(5):1554–61.
• Single‑dose cholecalciferol suppresses the winter increase in parathyroid hormone concentrations in healthy older men and women: a randomized trial.Am J Clin Nutr. 1994 May;59(5):1040–4.
• Effects of skin thickness, age, body fat, and sunlight on serum 25‑hydroxyvitamin D.Am J Clin Nutr. 1993 Dec;58(6):882–5.
• Selective biological response by target organs (intestine, kidney, and bone) to 1,25‑dihydroxyvitamin D3 and two analogues.Cancer Res. 1993 Sep 1;53(17):3935–42.
• Biological activity assessment of 1 alpha,25‑dihydroxyvitamin D3‑26,23‑lactone and its intermediate metabolites in vivo and in vitro.Endocrinology. 1990 Aug;127(2):695–701.
• The role of the vitamin D endocrine system in health and disease.N Engl J Med. 1989 Apr 13;320(15):980–91. Review.
• Synthesis and biological activity of 1 alpha,23,25,26‑tetrahydroxyvitamin D3.Arch Biochem Biophys. 1987 Apr;254(1):188–95.
• Photosynthesis of vitamin D in the skin: effect of environmental and life‑style variables.Fed Proc. 1987 Apr;46(5):1876–82.
• Synthesis of vitamin D by the skin.Wiad Lek. 1987 Mar 15;40(6):413–9. In Polish.
• The difference of biological activity among four diastereoisomers of 1 alpha,25‑dihydroxycholecalciferol‑26,23‑lactone.J Steroid Biochem. 1986 Oct;25(4):505–10.
• The metabolism and functions of vitamin D.Adv Exp Med Biol. 1986;196:361–75. Review.
• Vitamin D absorption in healthy subjects and in patients with intestinal malabsorption syndromes.Am J Clin Nutr. 1985 Oct;42(4):644–9.
• Aging decreases the capacity of human skin to produce vitamin D3.J Clin Invest. 1985 Oct;76(4):1536–8.
• Synthesis of Vitamin D in the skin.Postepy Hig Med Dosw. 1985 Jan–Feb;39(1):85–104. Review in Polish.
• Environmental light: effects on vitamin D synthesis and calcium metabolism in humans.Ann N Y Acad Sci. 1985;453:14–20.
• Metabolism of 1,25‑dihydroxyvitamin D3.Physiol Rev. 1984 Apr;64(2):478–504. Review.
• Measurement of vitamin D metabolites in anephric subjects.Nephron. 1984;36(4):230–4.
• Vitamin D: recent advances.Annu Rev Biochem. 1983;52:411–39. Review.
• Vitamin D from skin: contribution to vitamin D status compared with oral vitamin D in normal and anticonvulsant‑treated subjects.Clin Sci (Lond). 1982 Nov;63(5):461–72.
• Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin.Science. 1982 May 28;216(4549):1001–3.
• Vitamin‑D synthesis and metabolism after ultraviolet irradiation of normal and vitamin‑D‑deficient subjects.N Engl J Med. 1982 Mar 25;306(12):722–5.
• Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation.Mol Cell Endocrinol. 1982 Mar;25(3):295–302.
• Absence of seasonal variation in serum concentrations of 1,25‑dihydroxyvitamin D despite a rise in 25‑hydroxyvitamin D in summer.J Clin Endocrinol Metab. 1981 Jul;53(1):139–42.
• The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system.J Invest Dermatol. 1981 Jul;77(1):51–8.
• Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator.Science. 1981 Feb 6;211(4482):590–3.
• Photosynthesis of previtamin D3 in human skin and the physiologic consequences.Science. 1980 Oct 10;210(4466):203–5.
• Vitamin D metabolism in kidney insufficiency: disorders of an endocrine regulatory zone.Klin Wochenschr. 1979 Oct 1;57(19):1053–9. Review in German.
• Physiologic implications of the formation of previtamin D3 in skin.Trans Assoc Am Physicians. 1979;92:54–63.
• Previtamin D3 from skin.Nutr Rev. 1979 Jun;37(6):203–5.
• Interrelationships between the key elements of the vitamin D endocrine system: 25‑OH‑D3‑1‑hydroxylase, serum calcium and phosphorus levels, intestinal 1,25(OH)2D3, and intestinal calcium binding protein.Adv Exp Med Biol. 1977;81:211–31. Review.
• Regulation of vitamin D metabolism in the kidney.Adv Exp Med Biol. 1977;81:195–209. Review.
• The regulation of vitamin D metabolism.Adv Exp Med Biol. 1977;81:251–61.
• Metabolism of vitamin D: current status.Am J Clin Nutr. 1976 Nov;29(11):1258–70.
• Vitamin D: the discovery of its metabolites and their therapeutic applications.Pediatrics. 1976 May;57(5):729–41. Review.
• Recent advances in our understanding of the vitamin D endocrine system.J Lab Clin Med. 1976 Jan;87(1):7–26. Review.
• Factors in human vitamin D nutrition and in the production and cure of classical rickets.Proc Nutr Soc. 1975 Sep;34(2):119–30. Review.
• The kidney as an endocrine organ involved in the function of vitamin D.Am J Med. 1975 Jan;58(1):39–47. Review.
• Evidence for the biologically active form of cholecalciferol in the intestine.J Biol Chem. 1970 Mar 10;245(5):1190–6.
• Chromosomal receptor for a vitamin D metabolite.Proc Natl Acad Sci U S A. 1969 Jan;62(1):155–62.
• The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo.J Biol Chem. 1968 Aug 10;243(15):4055–64.

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