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Information on the latest vitamin D news and research.

Find out more information on deficiency, supplementation, sun exposure, and how vitamin D relates to your health.

I have body pain, muscle pain, bone pain, sleeplessness, brain fog, palpitations and mild depression. I have been tested for Vitamin D level by doctor and it came as 27 ng/ml. Doctor prescribed me weekly dose of 60000 I.U. Vitamin D3 supplement (Lumia 60K) for 8 weeks and then daily 1000 IU as maintenance dose. After 3 months of supplementation my Vitamin D level is 35 ng/ml and all my symptoms are persisting. This is the second time I got treated with Vitamin D 60000 IU and both the time the level does not increase 6-7 ng/ml after 8-10 weeks supplementation. I do have issue of NAFLD and my liver is mostly inflamed due to no obvious reason. All the hepatitis related tests are negative but triglyceride level is elevated (250). Ultrasound says only fatty infiltration in liver no. Surprisingly all my symptoms started within few months of my NAFLD diagnosis. Do you think Vitamin D level and NAFLD has any connection? Is that due to liver disease my Vitamin D level does not increase? Thanks.

Ask the Vitamin D Council

Asked by  sourish.mukherjee198344049300 on August 25, 2016

Answers
  •  sourish.mukherjee198344049300 on

    See title

    Answered by  sourish.mukherjee198344049300 on

  • IAW
    Participant
     IAW on

    First your maintenance dosage is not high enough.It needs to be at least 5000iu a DAY. I suspect that if someone measured your levels at eight weeks instead of 12 weeks, your level would be higher. The level starts to plummet again without the higher maintenance dosage.
    Now let me ask you this. By week seven of the eight week treatment, did you “feel” any better? Were your symptoms less?
    A Vitamin D deficiency can cause NAFLD. Even if you have NAFLD, your liver can still process Vitamin D. http://www.vitamindcouncil.org/?s=NAFLD&submit=Submit#blog.
    You should read http://www.vitamindcouncil.org/about-vitamin-d/vitamin-d-and-other-vitamins-and-minerals/. It is very important. (Get some supplemental magnesium and not oxide.)
    Taking 60,000iu once a week is about equal to taking 8500iu a day, with 10,000iu a day being the “official” safe upper limit. We do promote taking Vitamin D each day instead of once a week. It is better for you. I am not a doctor but here is what I would suggest knowing you have NAFLD.
    I would take the 10,000 iu a day until all of your symptoms disappear. (It could take a while for the NAFLD to resolve itself.) Then I would reduce it to 5000iu a day. If you get any symptoms back after that then you will need to take more Vitamin D on a daily basis.
    If you take the 10,000iu a day and nothing has changed in four weeks from now, then I would come back and tell me. You may need to take a higher amount. No one knows how much Vitamin D it takes to combat a “diseased state”.
    If anywhere along the way you have a “new” symptom come back and tell me. Sometimes Vitamin D can cause a mineral deficiency and then you will need supplements.

    Answered by  IAW on
  •  sourish.mukherjee198344049300 on

    Thank you very much for your reply. Unfortunately I have not got any benefit after taking 60000 IU for 8 weeks and that surprises me. Previously also I took the same dose for 8 weeks and never felt better. In that time it raised my Vitamin D to 36 ng/ml and within 2-3 months it came back to 22 ng/ml. The only coincidence is that in that time also my liver was inflamed and now also. I confirmed from the hepatologist that there is no serious liver injury or anything of that short. It is inflamed due to excessive fat accumulation. My bilirubin and SGPT level are always high and they are around 2.3-2.8 and 150-220. I have been treated with ursodeoxycholic acid,fenofibrate and anti-oxidants for around 6 months with very slight improvement.

    That’s why I got doubt whether Vitamin D is getting absorbed in my body or not. Not sure liver is stopping it to give health benefits.

    I am not sure whether I am taking the right form of Vitamin D, as I have some chronic liver issue.

    I will follow your advice. Please let me know your opinion.

    Thank you for your time and effort.

    Regards,

    Answered by  sourish.mukherjee198344049300 on

  • IAW
    Participant
     IAW on

    The internet shows that Lumia is Cholecalciferol which is D3 and that is what you want D3 and not D2.
    While taking it your levels did increase and that is a good sign. I think you just need to take it everyday and take a lot more.
    Straight from the blog http://www.vitamindcouncil.org/blog/the-importance-of-vitamin-d-status-in-liver-disease/, “The liver is able to metabolize vitamin D, even in advanced cirrhosis”.
    I usually aim to be conservative since I am not a doctor. I also did not ask if you weigh around the average of 150lbs. If not and you weigh a lot more, you will need to take a lot more Vitamin D on that fact alone. You can consider trying 15,000-20,000iu a day. (Science already knows that you would have to take 40,000iu every day for months before you might become toxic. Their are people using much higher amounts than that to cure their Multiple Sclerosis. I can also show you a study that used 35,000iu a day for I think 6 months, to treat psoriasis.) Just remember any new symptoms or symptoms get worse, come back and tell me. To be quite honest some of us do not function well on smaller amounts of Vitamin D but others do just fine.
    Let me know if you have any more questions.

    Answered by  IAW on