Researchers out of Turkey have found that low vitamin D levels are associated with higher mean platelet volume, especially among women.
Platelets are small cell fragments (cells that do not have a nucleus). They circulate in the blood and are involved in hemostasis, leading to the formation of blood clots.
Mean platelet volume (MPV) is the average size of the platelets in your blood. Platelet size increases when your body is producing more platelets, so MPV is a good measurement of overall platelet function.
Abnormally high MPV is associated with various cardiovascular diseases like coronary artery disease, hypertension and stroke. This is because larger platelets have a more difficult time traveling through your blood stream and can more easily get stuck and block your arteries.
An abnormally high MPV occurs when your body constantly creates new platelets (which are larger than older platelets) because of a continual loss of existing platelets. This can be caused by things like a recent surgery, infection, inflammation, or from heavy blood loss.